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The Burelle Lab recently initiated a new line of projects which aim to define how mitochondrial quality control pathways such as mitophagy shape the metabolic phenotype and behaviour of muscle stem cells (MuSCs), and whether these pathways can be targeted to improve muscle regeneration in the context of neuromuscular disorders, muscle injuries, and aging.  The projects involves in vitro studies in prurified MuSCs and single muscle fiber cultures as well as in vivo studies in mice harboring inducible MuSC-specific genetic knockouts. We are seeking a dynamic and motivated post doctoral fellow to drive some of these projects.

The candidate should have a marked interest for mitochondrial and stem cell biology and be confortable with the following techniques: Isolation purification and culture of primary cells, FACS, immunofluorescence, confocal imaging and standard molecular techniques. Knowledge in RNAseq, and proteomics is an asset.