Outline of current research
Our lab focusses on integrative mitochondrial biology. We have a strong expertise in the analysis of many facets of mitochondria, with the ability to combine detailed mechanistic studies with the analysis of functional repercussions in isolated organelles, permeabilized or intact cells, mouse models of disease, and fibroblasts or muscle biopsies from patients. Beyond bioenergetics and metabolism, we study processes such as ROS metabolism and permeability transition pore opening, as well as mitochondrial quality control mechanisms, such as mitophagy and the shedding of mitochondrial-derived vesicles.
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Role of Mitochondria in Muscle Stem Cells
Mitochondria have emerged as integration and signaling hubs playing a crucial role in the regulation of Muscle Stem Cell (MuSC) fate decision and myogenic lineage progression. Current research projects aim to delineate the role of mitophagy in MuSCs, and test whether stimulation of this process can improve their regenerative capacity.
Mitochondrial Quality Control Systems and Muscle Homeostasis
Using cardiac and skeletal muscle as working models, we are conducting studies to delineate the physiological role of various mitochondrial quality control mechanisms. Our curent work focusses on mitophagy and Mitochondrial-Derived Vesicles.
Genetic Mitochondrial Diseases
Together with a multidisciplinary team, we pursue studies aimed at better understanding the pathogenesis of Leigh Syndrome French Canadian (LSFC), identify biomarkers and therapeutic options to improve patient care.