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Mitochondrial Quality Control Systems and Muscle Homeostasis

Using cardiac and skeletal muscle as working models, we are conducting studies to delineate the physiological role of various mitochondrial quality control mechanisms. Our curent work focusses on mitophagy and Mitochondrial-Derived Vesicles using in vitro and in vivo studies combining imaging, proteomics and functional analyses.

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Proteins with hyper‐reactive cysteine residues are labeled with green and yellow borders, respectively

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Relevant publications

  1. Proteomics characterization of mitochondrial-derived vesicles under oxidative stress. Vasam G, Nadeau R, Cadete VJJ, Lavallée-Adam M, Menzies KJ, Burelle Y.FASEB J. 2021 Apr;35(4):e21278. doi: 10.1096/fj.202002151R.PMID: 33769614.

  2. Mitochondrial quality control in the cardiac system: An integrative view. Cadete VJJ, Vasam G, Menzies KJ, Burelle Y.Biochim Biophys Acta Mol Basis Dis. 2019 Apr 1;1865(4):782-796. doi: 10.1016/j.bbadis.2018.11.018. Epub 2018 Nov 22.

  3. Protective role of Parkin in skeletal muscle contractile and mitochondrial function. Gouspillou G, Godin R, Piquereau J, Picard M, Mofarrahi M, Mathew J, Purves-Smith FM, Sgarioto N, Hepple RT, Burelle Y, Hussain SNA.J Physiol. 2018 Jul;596(13):2565-2579. doi: 10.1113/JP275604. Epub 2018 May 30.PMID: 29682760

  4. Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction. Piquereau J, Godin R, Deschênes S, Bessi VL, Mofarrahi M, Hussain SN, Burelle Y.Autophagy. 2013 Nov 1;9(11):1837-51. doi: 10.4161/auto.26502. Epub 2013 Oct 3.PMID: 24121678

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